diff --git a/src/datanode/src/error.rs b/src/datanode/src/error.rs
index 61a4eae128..6c63e9115f 100644
--- a/src/datanode/src/error.rs
+++ b/src/datanode/src/error.rs
@@ -260,6 +260,14 @@ pub enum Error {
         source: BoxedError,
     },
 
+    #[snafu(display("Failed to handle batch ddl request, ddl_type: {}", ddl_type))]
+    HandleBatchDdlRequest {
+        #[snafu(implicit)]
+        location: Location,
+        source: BoxedError,
+        ddl_type: String,
+    },
+
     #[snafu(display("RegionId {} not found", region_id))]
     RegionNotFound {
         region_id: RegionId,
@@ -438,7 +446,8 @@ impl ErrorExt for Error {
             UnsupportedOutput { .. } => StatusCode::Unsupported,
             HandleRegionRequest { source, .. }
             | GetRegionMetadata { source, .. }
-            | HandleBatchOpenRequest { source, .. } => source.status_code(),
+            | HandleBatchOpenRequest { source, .. }
+            | HandleBatchDdlRequest { source, .. } => source.status_code(),
             StopRegionEngine { source, .. } => source.status_code(),
 
             FindLogicalRegions { source, .. } => source.status_code(),
diff --git a/src/datanode/src/region_server.rs b/src/datanode/src/region_server.rs
index f1eb63c51b..4c708002dd 100644
--- a/src/datanode/src/region_server.rs
+++ b/src/datanode/src/region_server.rs
@@ -59,7 +59,7 @@ use store_api::region_engine::{
     SettableRegionRoleState,
 };
 use store_api::region_request::{
-    AffectedRows, RegionCloseRequest, RegionOpenRequest, RegionRequest,
+    AffectedRows, BatchRegionDdlRequest, RegionCloseRequest, RegionOpenRequest, RegionRequest,
 };
 use store_api::storage::RegionId;
 use tokio::sync::{Semaphore, SemaphorePermit};
@@ -69,9 +69,10 @@ use tonic::{Request, Response, Result as TonicResult};
 use crate::error::{
     self, BuildRegionRequestsSnafu, ConcurrentQueryLimiterClosedSnafu,
     ConcurrentQueryLimiterTimeoutSnafu, DataFusionSnafu, DecodeLogicalPlanSnafu,
-    ExecuteLogicalPlanSnafu, FindLogicalRegionsSnafu, HandleBatchOpenRequestSnafu,
-    HandleRegionRequestSnafu, NewPlanDecoderSnafu, RegionEngineNotFoundSnafu, RegionNotFoundSnafu,
-    RegionNotReadySnafu, Result, StopRegionEngineSnafu, UnexpectedSnafu, UnsupportedOutputSnafu,
+    ExecuteLogicalPlanSnafu, FindLogicalRegionsSnafu, HandleBatchDdlRequestSnafu,
+    HandleBatchOpenRequestSnafu, HandleRegionRequestSnafu, NewPlanDecoderSnafu,
+    RegionEngineNotFoundSnafu, RegionNotFoundSnafu, RegionNotReadySnafu, Result,
+    StopRegionEngineSnafu, UnexpectedSnafu, UnsupportedOutputSnafu,
 };
 use crate::event_listener::RegionServerEventListenerRef;
 
@@ -344,62 +345,47 @@ impl RegionServer {
             .region_map
             .insert(region_id, RegionEngineWithStatus::Ready(engine));
     }
-}
-
-#[async_trait]
-impl RegionServerHandler for RegionServer {
-    async fn handle(&self, request: region_request::Body) -> ServerResult<RegionResponseV1> {
-        let is_parallel = matches!(
-            request,
-            region_request::Body::Inserts(_) | region_request::Body::Deletes(_)
-        );
-        let requests = RegionRequest::try_from_request_body(request)
-            .context(BuildRegionRequestsSnafu)
-            .map_err(BoxedError::new)
-            .context(ExecuteGrpcRequestSnafu)?;
 
+    async fn handle_batch_ddl_requests(
+        &self,
+        request: region_request::Body,
+    ) -> Result<RegionResponse> {
+        // Safety: we have already checked the request type in `RegionServer::handle()`.
+        let batch_request = BatchRegionDdlRequest::try_from_request_body(request)
+            .context(BuildRegionRequestsSnafu)?
+            .unwrap();
         let tracing_context = TracingContext::from_current_span();
 
-        let results = if is_parallel {
-            let join_tasks = requests.into_iter().map(|(region_id, req)| {
-                let self_to_move = self.clone();
-                let span = tracing_context.attach(info_span!(
-                    "RegionServer::handle_region_request",
-                    region_id = region_id.to_string()
-                ));
-                async move {
-                    self_to_move
-                        .handle_request(region_id, req)
-                        .trace(span)
-                        .await
-                }
-            });
+        let span = tracing_context.attach(info_span!("RegionServer::handle_batch_ddl_requests"));
+        self.inner
+            .handle_batch_request(batch_request)
+            .trace(span)
+            .await
+    }
 
-            try_join_all(join_tasks)
-                .await
-                .map_err(BoxedError::new)
-                .context(ExecuteGrpcRequestSnafu)?
-        } else {
-            let mut results = Vec::with_capacity(requests.len());
-            // FIXME(jeremy, ruihang): Once the engine supports merged calls, we should immediately
-            // modify this part to avoid inefficient serial loop calls.
-            for (region_id, req) in requests {
-                let span = tracing_context.attach(info_span!(
-                    "RegionServer::handle_region_request",
-                    region_id = region_id.to_string()
-                ));
-                let result = self
+    async fn handle_requests_in_parallel(
+        &self,
+        request: region_request::Body,
+    ) -> Result<RegionResponse> {
+        let requests =
+            RegionRequest::try_from_request_body(request).context(BuildRegionRequestsSnafu)?;
+        let tracing_context = TracingContext::from_current_span();
+
+        let join_tasks = requests.into_iter().map(|(region_id, req)| {
+            let self_to_move = self;
+            let span = tracing_context.attach(info_span!(
+                "RegionServer::handle_region_request",
+                region_id = region_id.to_string()
+            ));
+            async move {
+                self_to_move
                     .handle_request(region_id, req)
                     .trace(span)
                     .await
-                    .map_err(BoxedError::new)
-                    .context(ExecuteGrpcRequestSnafu)?;
-                results.push(result);
             }
-            results
-        };
+        });
 
-        // merge results by sum up affected rows and merge extensions.
+        let results = try_join_all(join_tasks).await?;
         let mut affected_rows = 0;
         let mut extensions = HashMap::new();
         for result in results {
@@ -407,6 +393,57 @@ impl RegionServerHandler for RegionServer {
             extensions.extend(result.extensions);
         }
 
+        Ok(RegionResponse {
+            affected_rows,
+            extensions,
+        })
+    }
+
+    async fn handle_requests_in_serial(
+        &self,
+        request: region_request::Body,
+    ) -> Result<RegionResponse> {
+        let requests =
+            RegionRequest::try_from_request_body(request).context(BuildRegionRequestsSnafu)?;
+        let tracing_context = TracingContext::from_current_span();
+
+        let mut affected_rows = 0;
+        let mut extensions = HashMap::new();
+        // FIXME(jeremy, ruihang): Once the engine supports merged calls, we should immediately
+        // modify this part to avoid inefficient serial loop calls.
+        for (region_id, req) in requests {
+            let span = tracing_context.attach(info_span!(
+                "RegionServer::handle_region_request",
+                region_id = region_id.to_string()
+            ));
+            let result = self.handle_request(region_id, req).trace(span).await?;
+
+            affected_rows += result.affected_rows;
+            extensions.extend(result.extensions);
+        }
+
+        Ok(RegionResponse {
+            affected_rows,
+            extensions,
+        })
+    }
+}
+
+#[async_trait]
+impl RegionServerHandler for RegionServer {
+    async fn handle(&self, request: region_request::Body) -> ServerResult<RegionResponseV1> {
+        let response = match &request {
+            region_request::Body::Creates(_)
+            | region_request::Body::Drops(_)
+            | region_request::Body::Alters(_) => self.handle_batch_ddl_requests(request).await,
+            region_request::Body::Inserts(_) | region_request::Body::Deletes(_) => {
+                self.handle_requests_in_parallel(request).await
+            }
+            _ => self.handle_requests_in_serial(request).await,
+        }
+        .map_err(BoxedError::new)
+        .context(ExecuteGrpcRequestSnafu)?;
+
         Ok(RegionResponseV1 {
             header: Some(ResponseHeader {
                 status: Some(Status {
@@ -414,8 +451,8 @@ impl RegionServerHandler for RegionServer {
                     ..Default::default()
                 }),
             }),
-            affected_rows: affected_rows as _,
-            extensions,
+            affected_rows: response.affected_rows as _,
+            extensions: response.extensions,
         })
     }
 }
@@ -727,6 +764,71 @@ impl RegionServerInner {
             .collect::<Vec<_>>())
     }
 
+    // Handle requests in batch.
+    //
+    // limitation: all create requests must be in the same engine.
+    pub async fn handle_batch_request(
+        &self,
+        batch_request: BatchRegionDdlRequest,
+    ) -> Result<RegionResponse> {
+        let region_changes = match &batch_request {
+            BatchRegionDdlRequest::Create(requests) => requests
+                .iter()
+                .map(|(region_id, create)| {
+                    let attribute = parse_region_attribute(&create.engine, &create.options)?;
+                    Ok((*region_id, RegionChange::Register(attribute)))
+                })
+                .collect::<Result<Vec<_>>>()?,
+            BatchRegionDdlRequest::Drop(requests) => requests
+                .iter()
+                .map(|(region_id, _)| (*region_id, RegionChange::Deregisters))
+                .collect::<Vec<_>>(),
+            BatchRegionDdlRequest::Alter(requests) => requests
+                .iter()
+                .map(|(region_id, _)| (*region_id, RegionChange::None))
+                .collect::<Vec<_>>(),
+        };
+
+        // The ddl procedure will ensure all requests are in the same engine.
+        // Therefore, we can get the engine from the first request.
+        let (first_region_id, first_region_change) = region_changes.first().unwrap();
+        let engine = match self.get_engine(*first_region_id, first_region_change)? {
+            CurrentEngine::Engine(engine) => engine,
+            CurrentEngine::EarlyReturn(rows) => return Ok(RegionResponse::new(rows)),
+        };
+
+        for (region_id, region_change) in region_changes.iter() {
+            self.set_region_status_not_ready(*region_id, &engine, region_change);
+        }
+
+        let ddl_type = batch_request.request_type();
+        let result = engine
+            .handle_batch_ddl_requests(batch_request)
+            .await
+            .context(HandleBatchDdlRequestSnafu { ddl_type });
+
+        match result {
+            Ok(result) => {
+                for (region_id, region_change) in region_changes {
+                    self.set_region_status_ready(region_id, engine.clone(), region_change)
+                        .await?;
+                }
+
+                Ok(RegionResponse {
+                    affected_rows: result.affected_rows,
+                    extensions: result.extensions,
+                })
+            }
+            Err(err) => {
+                for (region_id, region_change) in region_changes {
+                    self.unset_region_status(region_id, &engine, region_change);
+                }
+
+                Err(err)
+            }
+        }
+    }
+
     pub async fn handle_request(
         &self,
         region_id: RegionId,
diff --git a/src/store-api/src/region_engine.rs b/src/store-api/src/region_engine.rs
index c9b0ac53db..46411d064b 100644
--- a/src/store-api/src/region_engine.rs
+++ b/src/store-api/src/region_engine.rs
@@ -15,6 +15,7 @@
 //! Region Engine's definition
 
 use std::any::Any;
+use std::collections::HashMap;
 use std::fmt::{Debug, Display};
 use std::sync::{Arc, Mutex};
 
@@ -33,7 +34,7 @@ use tokio::sync::Semaphore;
 
 use crate::logstore::entry;
 use crate::metadata::RegionMetadataRef;
-use crate::region_request::{RegionOpenRequest, RegionRequest};
+use crate::region_request::{BatchRegionDdlRequest, RegionOpenRequest, RegionRequest};
 use crate::storage::{RegionId, ScanRequest};
 
 /// The settable region role state.
@@ -407,6 +408,27 @@ pub trait RegionEngine: Send + Sync {
         Ok(join_all(tasks).await)
     }
 
+    async fn handle_batch_ddl_requests(
+        &self,
+        request: BatchRegionDdlRequest,
+    ) -> Result<RegionResponse, BoxedError> {
+        let requests = request.into_region_requests();
+
+        let mut affected_rows = 0;
+        let mut extensions = HashMap::new();
+
+        for (region_id, request) in requests {
+            let result = self.handle_request(region_id, request).await?;
+            affected_rows += result.affected_rows;
+            extensions.extend(result.extensions);
+        }
+
+        Ok(RegionResponse {
+            affected_rows,
+            extensions,
+        })
+    }
+
     /// Handles non-query request to the region. Returns the count of affected rows.
     async fn handle_request(
         &self,
diff --git a/src/store-api/src/region_request.rs b/src/store-api/src/region_request.rs
index b391441bd5..58afdaf128 100644
--- a/src/store-api/src/region_request.rs
+++ b/src/store-api/src/region_request.rs
@@ -47,6 +47,67 @@ use crate::mito_engine_options::{
 use crate::path_utils::region_dir;
 use crate::storage::{ColumnId, RegionId, ScanRequest};
 
+#[derive(Debug, IntoStaticStr)]
+pub enum BatchRegionDdlRequest {
+    Create(Vec<(RegionId, RegionCreateRequest)>),
+    Drop(Vec<(RegionId, RegionDropRequest)>),
+    Alter(Vec<(RegionId, RegionAlterRequest)>),
+}
+
+impl BatchRegionDdlRequest {
+    /// Converts [Body](region_request::Body) to [`BatchRegionDdlRequest`].
+    pub fn try_from_request_body(body: region_request::Body) -> Result<Option<Self>> {
+        match body {
+            region_request::Body::Creates(creates) => {
+                let requests = creates
+                    .requests
+                    .into_iter()
+                    .map(parse_region_create)
+                    .collect::<Result<Vec<_>>>()?;
+                Ok(Some(Self::Create(requests)))
+            }
+            region_request::Body::Drops(drops) => {
+                let requests = drops
+                    .requests
+                    .into_iter()
+                    .map(parse_region_drop)
+                    .collect::<Result<Vec<_>>>()?;
+                Ok(Some(Self::Drop(requests)))
+            }
+            region_request::Body::Alters(alters) => {
+                let requests = alters
+                    .requests
+                    .into_iter()
+                    .map(parse_region_alter)
+                    .collect::<Result<Vec<_>>>()?;
+                Ok(Some(Self::Alter(requests)))
+            }
+            _ => Ok(None),
+        }
+    }
+
+    pub fn request_type(&self) -> &'static str {
+        self.into()
+    }
+
+    pub fn into_region_requests(self) -> Vec<(RegionId, RegionRequest)> {
+        match self {
+            Self::Create(requests) => requests
+                .into_iter()
+                .map(|(region_id, request)| (region_id, RegionRequest::Create(request)))
+                .collect(),
+            Self::Drop(requests) => requests
+                .into_iter()
+                .map(|(region_id, request)| (region_id, RegionRequest::Drop(request)))
+                .collect(),
+            Self::Alter(requests) => requests
+                .into_iter()
+                .map(|(region_id, request)| (region_id, RegionRequest::Alter(request)))
+                .collect(),
+        }
+    }
+}
+
 #[derive(Debug, IntoStaticStr)]
 pub enum RegionRequest {
     Put(RegionPutRequest),
@@ -123,7 +184,7 @@ fn make_region_deletes(deletes: DeleteRequests) -> Result<Vec<(RegionId, RegionR
     Ok(requests)
 }
 
-fn make_region_create(create: CreateRequest) -> Result<Vec<(RegionId, RegionRequest)>> {
+fn parse_region_create(create: CreateRequest) -> Result<(RegionId, RegionCreateRequest)> {
     let column_metadatas = create
         .column_defs
         .into_iter()
@@ -131,16 +192,21 @@ fn make_region_create(create: CreateRequest) -> Result<Vec<(RegionId, RegionRequ
         .collect::<Result<Vec<_>>>()?;
     let region_id = create.region_id.into();
     let region_dir = region_dir(&create.path, region_id);
-    Ok(vec![(
+    Ok((
         region_id,
-        RegionRequest::Create(RegionCreateRequest {
+        RegionCreateRequest {
             engine: create.engine,
             column_metadatas,
             primary_key: create.primary_key,
             options: create.options,
             region_dir,
-        }),
-    )])
+        },
+    ))
+}
+
+fn make_region_create(create: CreateRequest) -> Result<Vec<(RegionId, RegionRequest)>> {
+    let (region_id, request) = parse_region_create(create)?;
+    Ok(vec![(region_id, RegionRequest::Create(request))])
 }
 
 fn make_region_creates(creates: CreateRequests) -> Result<Vec<(RegionId, RegionRequest)>> {
@@ -151,9 +217,14 @@ fn make_region_creates(creates: CreateRequests) -> Result<Vec<(RegionId, RegionR
     Ok(requests)
 }
 
-fn make_region_drop(drop: DropRequest) -> Result<Vec<(RegionId, RegionRequest)>> {
+fn parse_region_drop(drop: DropRequest) -> Result<(RegionId, RegionDropRequest)> {
     let region_id = drop.region_id.into();
-    Ok(vec![(region_id, RegionRequest::Drop(RegionDropRequest {}))])
+    Ok((region_id, RegionDropRequest {}))
+}
+
+fn make_region_drop(drop: DropRequest) -> Result<Vec<(RegionId, RegionRequest)>> {
+    let (region_id, request) = parse_region_drop(drop)?;
+    Ok(vec![(region_id, RegionRequest::Drop(request))])
 }
 
 fn make_region_drops(drops: DropRequests) -> Result<Vec<(RegionId, RegionRequest)>> {
@@ -186,12 +257,15 @@ fn make_region_close(close: CloseRequest) -> Result<Vec<(RegionId, RegionRequest
     )])
 }
 
-fn make_region_alter(alter: AlterRequest) -> Result<Vec<(RegionId, RegionRequest)>> {
+fn parse_region_alter(alter: AlterRequest) -> Result<(RegionId, RegionAlterRequest)> {
     let region_id = alter.region_id.into();
-    Ok(vec![(
-        region_id,
-        RegionRequest::Alter(RegionAlterRequest::try_from(alter)?),
-    )])
+    let request = RegionAlterRequest::try_from(alter)?;
+    Ok((region_id, request))
+}
+
+fn make_region_alter(alter: AlterRequest) -> Result<Vec<(RegionId, RegionRequest)>> {
+    let (region_id, request) = parse_region_alter(alter)?;
+    Ok(vec![(region_id, RegionRequest::Alter(request))])
 }
 
 fn make_region_alters(alters: AlterRequests) -> Result<Vec<(RegionId, RegionRequest)>> {