diff --git a/.github/workflows/build_and_test.yml b/.github/workflows/build_and_test.yml
index 2b88f09b3d..e8feef98b9 100644
--- a/.github/workflows/build_and_test.yml
+++ b/.github/workflows/build_and_test.yml
@@ -341,7 +341,9 @@ jobs:
 
       - name: Run rust tests
         run: |
-          ${cov_prefix} cargo nextest run $CARGO_FLAGS $CARGO_FEATURES
+          for io_engine in std-fs tokio-epoll-uring ; do
+            NEON_PAGESERVER_UNIT_TEST_VIRTUAL_FILE_IOENGINE=$io_engine ${cov_prefix} cargo nextest run $CARGO_FLAGS $CARGO_FEATURES
+          done
 
           # Run separate tests for real S3
           export ENABLE_REAL_S3_REMOTE_STORAGE=nonempty
@@ -426,6 +428,7 @@ jobs:
       matrix:
         build_type: [ debug, release ]
         pg_version: [ v14, v15, v16 ]
+        pageserver_virtual_file_io_engine: [ std-fs, tokio-epoll-uring ]
     steps:
       - name: Checkout
         uses: actions/checkout@v3
@@ -448,6 +451,7 @@ jobs:
           TEST_RESULT_CONNSTR: ${{ secrets.REGRESS_TEST_RESULT_CONNSTR_NEW }}
           CHECK_ONDISK_DATA_COMPATIBILITY: nonempty
           BUILD_TAG: ${{ needs.tag.outputs.build-tag }}
+          PAGESERVER_VIRTUAL_FILE_IO_ENGINE: ${{ matrix.pageserver_virtual_file_io_engine }}
 
       - name: Merge and upload coverage data
         if: matrix.build_type == 'debug' && matrix.pg_version == 'v14'
@@ -464,8 +468,10 @@ jobs:
     strategy:
       fail-fast: false
       matrix:
+        # the amount of groups (N) should be reflected in `extra_params: --splits N ...`
         pytest_split_group: [ 1, 2, 3, 4 ]
         build_type: [ release ]
+        pageserver_virtual_file_io_engine: [ std-fs, tokio-epoll-uring ]
     steps:
       - name: Checkout
         uses: actions/checkout@v3
@@ -477,11 +483,12 @@ jobs:
           test_selection: performance
           run_in_parallel: false
           save_perf_report: ${{ github.ref_name == 'main' }}
-          extra_params: --splits ${{ strategy.job-total }} --group ${{ matrix.pytest_split_group }}
+          extra_params: --splits 4 --group ${{ matrix.pytest_split_group }}
         env:
           VIP_VAP_ACCESS_TOKEN: "${{ secrets.VIP_VAP_ACCESS_TOKEN }}"
           PERF_TEST_RESULT_CONNSTR: "${{ secrets.PERF_TEST_RESULT_CONNSTR }}"
           TEST_RESULT_CONNSTR: "${{ secrets.REGRESS_TEST_RESULT_CONNSTR_NEW }}"
+          PAGESERVER_VIRTUAL_FILE_IO_ENGINE: "${{ matrix.pageserver_virtual_file_io_engine }}"
       # XXX: no coverage data handling here, since benchmarks are run on release builds,
       # while coverage is currently collected for the debug ones
 
diff --git a/scripts/flaky_tests.py b/scripts/flaky_tests.py
index b07e4bea9b..61a97f520d 100755
--- a/scripts/flaky_tests.py
+++ b/scripts/flaky_tests.py
@@ -3,6 +3,7 @@
 import argparse
 import json
 import logging
+import os
 from collections import defaultdict
 from typing import DefaultDict, Dict
 
@@ -45,6 +46,15 @@ def main(args: argparse.Namespace):
         logging.error("cannot fetch flaky tests from the DB due to an error", exc)
         rows = []
 
+    # If a test run has non-default PAGESERVER_VIRTUAL_FILE_IO_ENGINE (i.e. not empty, not std-fs),
+    # use it to parametrize test name along with build_type and pg_version
+    #
+    # See test_runner/fixtures/parametrize.py for details
+    if (io_engine := os.getenv("PAGESERVER_VIRTUAL_FILE_IO_ENGINE", "")) not in ("", "std-fs"):
+        pageserver_virtual_file_io_engine_parameter = f"-{io_engine}"
+    else:
+        pageserver_virtual_file_io_engine_parameter = ""
+
     for row in rows:
         # We don't want to automatically rerun tests in a performance suite
         if row["parent_suite"] != "test_runner.regress":
@@ -53,10 +63,10 @@ def main(args: argparse.Namespace):
         if row["name"].endswith("]"):
             parametrized_test = row["name"].replace(
                 "[",
-                f"[{build_type}-pg{pg_version}-",
+                f"[{build_type}-pg{pg_version}{pageserver_virtual_file_io_engine_parameter}-",
             )
         else:
-            parametrized_test = f"{row['name']}[{build_type}-pg{pg_version}]"
+            parametrized_test = f"{row['name']}[{build_type}-pg{pg_version}{pageserver_virtual_file_io_engine_parameter}]"
 
         res[row["parent_suite"]][row["suite"]][parametrized_test] = True
 
diff --git a/test_runner/fixtures/neon_fixtures.py b/test_runner/fixtures/neon_fixtures.py
index 553a6e0712..6237ff53f2 100644
--- a/test_runner/fixtures/neon_fixtures.py
+++ b/test_runner/fixtures/neon_fixtures.py
@@ -1073,6 +1073,7 @@ def _shared_simple_env(
     neon_binpath: Path,
     pg_distrib_dir: Path,
     pg_version: PgVersion,
+    pageserver_virtual_file_io_engine: str,
 ) -> Iterator[NeonEnv]:
     """
     # Internal fixture backing the `neon_simple_env` fixture. If TEST_SHARED_FIXTURES
@@ -1101,6 +1102,7 @@ def _shared_simple_env(
         preserve_database_files=pytestconfig.getoption("--preserve-database-files"),
         test_name=request.node.name,
         test_output_dir=test_output_dir,
+        pageserver_virtual_file_io_engine=pageserver_virtual_file_io_engine,
     ) as builder:
         env = builder.init_start()
 
@@ -1138,6 +1140,7 @@ def neon_env_builder(
     run_id: uuid.UUID,
     request: FixtureRequest,
     test_overlay_dir: Path,
+    pageserver_virtual_file_io_engine: str,
 ) -> Iterator[NeonEnvBuilder]:
     """
     Fixture to create a Neon environment for test.
@@ -1166,6 +1169,7 @@ def neon_env_builder(
         broker=default_broker,
         run_id=run_id,
         preserve_database_files=pytestconfig.getoption("--preserve-database-files"),
+        pageserver_virtual_file_io_engine=pageserver_virtual_file_io_engine,
         test_name=request.node.name,
         test_output_dir=test_output_dir,
         test_overlay_dir=test_overlay_dir,
diff --git a/test_runner/fixtures/parametrize.py b/test_runner/fixtures/parametrize.py
index 53350138dd..d8ac92abb6 100644
--- a/test_runner/fixtures/parametrize.py
+++ b/test_runner/fixtures/parametrize.py
@@ -8,7 +8,7 @@ from _pytest.python import Metafunc
 from fixtures.pg_version import PgVersion
 
 """
-Dynamically parametrize tests by Postgres version and build type (debug/release/remote)
+Dynamically parametrize tests by Postgres version, build type (debug/release/remote), and possibly by other parameters
 """
 
 
@@ -31,11 +31,12 @@ def build_type(request: FixtureRequest) -> Optional[str]:
     return None
 
 
-def pytest_generate_tests(metafunc: Metafunc):
-    # Do not parametrize performance tests yet, we need to prepare grafana charts first
-    if "test_runner/performance" in metafunc.definition._nodeid:
-        return
+@pytest.fixture(scope="function", autouse=True)
+def pageserver_virtual_file_io_engine(request: FixtureRequest) -> Optional[str]:
+    return None
 
+
+def pytest_generate_tests(metafunc: Metafunc):
     if (v := os.environ.get("DEFAULT_PG_VERSION")) is None:
         pg_versions = [version for version in PgVersion if version != PgVersion.NOT_SET]
     else:
@@ -46,5 +47,12 @@ def pytest_generate_tests(metafunc: Metafunc):
     else:
         build_types = [bt.lower()]
 
-    metafunc.parametrize("build_type", build_types)
-    metafunc.parametrize("pg_version", pg_versions, ids=map(lambda v: f"pg{v}", pg_versions))
+    # Do not parametrize performance tests yet by Postgres version or build type, we need to prepare grafana charts first
+    if "test_runner/performance" not in metafunc.definition._nodeid:
+        metafunc.parametrize("build_type", build_types)
+        metafunc.parametrize("pg_version", pg_versions, ids=map(lambda v: f"pg{v}", pg_versions))
+
+    # A hacky way to parametrize tests only for `pageserver_virtual_file_io_engine=tokio-epoll-uring`
+    # And do not change test name for default `pageserver_virtual_file_io_engine=std-fs` to keep tests statistics
+    if (io_engine := os.environ.get("PAGESERVER_VIRTUAL_FILE_IO_ENGINE", "")) not in ("", "std-fs"):
+        metafunc.parametrize("pageserver_virtual_file_io_engine", [io_engine])