diff --git a/locales/rn/de.json b/locales/rn/de.json
index 8193bd8f..2391303f 100644
--- a/locales/rn/de.json
+++ b/locales/rn/de.json
@@ -616,6 +616,9 @@
       "your_server": "Ihrem Server"
     }
   },
+  "notifications": {
+    "vacation_filters_off": "Abwesenheits-Einstellungen gespeichert, aber Ihre Filter sind ausgeschaltet. Speichern Sie noch einmal, um sie wieder einzuschalten."
+  },
   "offline": {
     "banner": "Sie sind offline",
     "discarded_changes": "{count, plural, one {# Offline-Änderung wurde} other {# Offline-Änderungen wurden}} verworfen, weil sich der Mailserver geändert hat",
diff --git a/locales/rn/en.json b/locales/rn/en.json
index 84ffef24..a3e7c40c 100644
--- a/locales/rn/en.json
+++ b/locales/rn/en.json
@@ -661,6 +661,9 @@
       "your_server": "your server"
     }
   },
+  "notifications": {
+    "vacation_filters_off": "Out of office settings saved, but your filters are switched off. Save again to turn them back on."
+  },
   "offline": {
     "banner": "You are offline",
     "discarded_changes": "{count, plural, one {# offline change was} other {# offline changes were}} discarded because the mail server changed",
diff --git a/src/components/settings/VacationSettings.tsx b/src/components/settings/VacationSettings.tsx
index 60aef49e..3b8ae54c 100644
--- a/src/components/settings/VacationSettings.tsx
+++ b/src/components/settings/VacationSettings.tsx
@@ -192,7 +192,9 @@ export function VacationSettings() {
       Alert.alert(t('notifications.vacation_saved', 'Vacation responder settings saved'));
     } catch (err) {
       Alert.alert(
-        err instanceof VacationFiltersError
+        err instanceof VacationFiltersError && err.filtersOff
+          ? t('notifications.vacation_filters_off', 'Out of office settings saved, but your filters are switched off. Save again to turn them back on.')
+          : err instanceof VacationFiltersError
           ? t('notifications.vacation_filters_save_failed', 'Out of office settings saved, but the forwarding and reply recipients could not be saved')
           : t('notifications.vacation_save_failed', 'Failed to save vacation responder settings'),
         err instanceof Error ? err.message : undefined,
diff --git a/src/stores/__tests__/vacation-store.test.ts b/src/stores/__tests__/vacation-store.test.ts
index 8044e013..31ef0a8c 100644
--- a/src/stores/__tests__/vacation-store.test.ts
+++ b/src/stores/__tests__/vacation-store.test.ts
@@ -21,7 +21,7 @@ vi.mock('../filter-store', () => ({
 import * as vacation from '../../api/vacation';
 import * as sieve from '../../api/sieve';
 import * as filters from '../filter-store';
-import { useVacationStore } from '../vacation-store';
+import { useVacationStore, VacationFiltersError } from '../vacation-store';
 
 const api = vi.mocked(vacation);
 const sieveApi = vi.mocked(sieve);
@@ -164,6 +164,21 @@ describe('vacation-store and the filters script (webmail 198a3c0d)', () => {
     );
   });
 
+  // Turning the auto-reply on activates Stalwart's vacation script, which
+  // switches the filters off until the filters script includes it.
+  it('reports filters left off when the auto-reply was turned on', async () => {
+    sieveApi.isSieveSupported.mockReturnValue(true);
+    filterStore.syncVacationWithFilters.mockRejectedValueOnce(new Error('boom'));
+    const warn = vi.spyOn(console, 'warn').mockImplementation(() => {});
+
+    const saved = useVacationStore.getState().save({ isEnabled: true });
+    await expect(saved).rejects.toBeInstanceOf(VacationFiltersError);
+    await expect(saved).rejects.toMatchObject({ filtersOff: true });
+    expect(api.setVacationResponse).toHaveBeenCalledWith({ isEnabled: true }, undefined);
+    expect(useVacationStore.getState()).toMatchObject({ isEnabled: true, isSaving: false });
+    warn.mockRestore();
+  });
+
   it('reports a forwarding that could not be saved', async () => {
     sieveApi.isSieveSupported.mockReturnValue(true);
     filterStore.syncVacationWithFilters.mockRejectedValueOnce(new Error('boom'));
diff --git a/src/stores/vacation-store.ts b/src/stores/vacation-store.ts
index 4b73a1b6..ff7c549b 100644
--- a/src/stores/vacation-store.ts
+++ b/src/stores/vacation-store.ts
@@ -19,9 +19,17 @@ export type VacationForwardSettings = Pick<VacationForward, 'enabled' | 'to' | '
  * or still run, and the auto-reply may go to the wrong senders.
  */
 export class VacationFiltersError extends Error {
-  constructor(cause: unknown) {
+  /**
+   * The auto-reply was turned on and the filters script could not be made
+   * to run next to it: Stalwart's vacation script took over, and no filter
+   * runs until the card is saved again.
+   */
+  readonly filtersOff: boolean;
+
+  constructor(cause: unknown, filtersOff = false) {
     super(cause instanceof Error ? cause.message : 'Failed to save the forwarding');
     this.name = 'VacationFiltersError';
+    this.filtersOff = filtersOff;
   }
 }
 
@@ -169,6 +177,9 @@ export const useVacationStore = create<VacationState>((set, get) => ({
     let filtersError: VacationFiltersError | null = null;
     let filtersState: Partial<VacationState> = {};
     const needsSync = vacationUpdates.isEnabled !== undefined || forwardSettings !== undefined || audience !== undefined;
+    // Turning the auto-reply on activates Stalwart's vacation script, which
+    // switches the filters off until the sync includes it in them again.
+    const turnedOn = vacationUpdates.isEnabled === true;
     if (needsSync && isSieveSupported(accountId)) {
       let synced = false;
       try {
@@ -180,9 +191,9 @@ export const useVacationStore = create<VacationState>((set, get) => ({
         console.warn('[vacation] Failed to keep filters active next to the vacation response:', err);
         // Forwarding that is or was on may now not run, or still run; an
         // auto-reply meant for some senders may go to everyone, or the other
-        // way round.
-        if (forwardSettings?.enabled || state.forward?.enabled || audience || state.audience) {
-          filtersError = new VacationFiltersError(err);
+        // way round; the filters may be off.
+        if (turnedOn || forwardSettings?.enabled || state.forward?.enabled || audience || state.audience) {
+          filtersError = new VacationFiltersError(err, turnedOn);
         }
       }
       // What the filters script holds now, and whether it runs. After a